The researchers have discovered an innovative way to guard the hair follicle against the harms of chemotherapy in an attempt to prevent hair loss as an outcome of cancer treatments. Scientists from the UMAN (University of Manchester) found out a novel tactic for how to prevent hair follicles from chemotherapy, which can pave the paths for new treatments that impede chemotherapy-induced hair loss—which are possibly one of the most psychologically agonizing side effects of modern cancer therapy. The study was published in the journal EMBO Molecular Medicine.
The research—at the laboratory of Professor Ralf Paus from the Centre for Dermatology Research—how the damage into the hair follicles induced by cancer drugs such as taxanes can cause unending hair loss, can be avoided. To do this, the researchers used the characteristics of a newer class of drugs known as CDK4/6 inhibitors, which stops cell division and are medically sanctioned as so-called “targeted” cancer therapies. Dr. Talveen Purba—Lead Author of the study—stated, “Though at first, this appeared as counter-intuitive, we discovered that CDK4/6 inhibitors can be utilized provisionally to stop cell division without promoting extra toxic outcomes in the hair follicle. On bathing the organ-cultured hair follicles of human scalp in CDK4/6 inhibitors, the follicles were quite less vulnerable to the damaging effects of taxanes.”
On a similar note, recently, a study showed that cancer patients’ hair loss misery during chemotherapy can be avoided. The investigators at the HUD (University of Huddersfield) focused to minimize or eliminate the hair loss completely, which is one of the most painful side-effects of cancer treatment. They aimed to accomplish this by merging scalp cooling—which earlier offered effective results in half of all cases—with a specifically formulated lotion or shampoo that could be applied to the scalp.